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. 2014 Aug 1;14:279. doi: 10.1186/1472-6882-14-279

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© Sui et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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ZJW reversed constitutive as well as PI3K/Akt pathway-induced MDR phenotype. (A) Anti-proliferative IC₅₀ values of L-OHP on HCT116/L-OHP cell treated with LY294002 (20 μM, 2 h), ZJW (50 μg/mL, 48 h), and a combination of ZJW (50 μg/mL, 48 h) and IGF-1 (100 ng/mL, 48 h), were analyzed by CCK-8. Data are presented as mean ± SD of triplicate experiments. **P < 0.01 vs. control, ^# P < 0.05 vs. ZJW group. (B) Flow cytometry analysis of apoptosis with Annexin V-FITC/PI binding to HCT116/L-OHP cells treated with LY294002 (20 μM, 2 h), ZJW (50 μg/mL, 48 h), and a combination of ZJW (50 μg/mL, 48 h) and IGF-1 (100 ng/mL, 48 h).