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Proposed model for acyltrehalose biosynthesis and transmembrane transport. The data are most consistent with a model in which Chp2 completes PAT biosynthesis in the cytosolic leaflet and MmpL10 transports acyltrehaloses across the membrane. The AcTre side products generated by Chp2 can be recycled by PapA3. (Note that the mycolipenic groups are truncated in this figure for simplicity.) OM, outer membrane.
