Table 2. Model parameters of the reaction-diffusion equations.
Parameter | Symbol | Value | Unit |
Diffusion coefficient | 223 106 | nm2/s | |
Cytosolic resting Ca2+ | 0.02 | µM | |
ER resting Ca2+ | 700 | µM | |
Diffusion coefficient | nm2/s | ||
Total concentration | 200 | µM | |
On-rate | 150 | 1/(µMs) | |
Off-rate | 300 | 1/s | |
IP3R pore radius | 6 | nm | |
Channel flux coefficient | 4.58 106 | nm/s | |
Channel current | 0.07 | pA | |
SERCA pump coefficient | 20,000 | nm/s | |
SERCA pump dissociation | 0.05 | µM | |
Leak flux coefficient | 903 | nm/s | |
Domain size | µm 3 | ||
# of IP3R channels | 1 | ||
inter channel distance | 120 | nm |