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. 2015 Jan 8;11(1):e1004005. doi: 10.1371/journal.pcbi.1004005

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© 2015 Mahoney et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Several genes bridge the component subnetworks of the molecular network. PLAUR is a gene that contains SSc-associated polymorphisms that forms a bridge between the interferon subnetwork and TGFβ/ECM subnetwork. The gene RAC2 is a bridge between the interferon and M2 macrophage subnetworks. The genes LCP2 and CXCR4 are bridges between the M2 macrophage subnetwork and the adaptive immunity subnetwork. There are also several paths through GRB10 to ADAP2 between the M2 macrophage subnetwork and the adaptive immunity subnetwork. The genes CD14 and THY1 (CD90) are bridges between the M2 macrophage subnetwork and the TGFβ/ECM subnetwork. The genes IRAK1 and PXK are bridges between the TGFβ/ECM subnetwork and the cell proliferation subnetwork.