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. Author manuscript; available in PMC: 2015 Jan 10.
Published in final edited form as: Cent Nerv Syst Agents Med Chem. 2012 Jun;12(2):122–130. doi: 10.2174/187152412800792742

Fig. (1).

Fig. (1)

The time courses of [MnTBAP] changes following administration. The animal experiment, agent administration, sample collection, and HPLC analysis are described in Materials and Methods. MnTBAP (6.4 mg/kg) was administered (iv) immediately after SCI (25 g․cm). Blood samples were drawn through a PE-10 tube from the tail artery and CSF was sampled through another PE-10 tube mounted on the atlanto-occipital membrane. MnTBAP in collected blood or in CSF was analyzed by HPLC with UV detection. a. The time courses of [MnTBAP] changes in blood and CSF samples from sham control and SCI animals, which show stable MnTBAP concentrations in CSF and blood post-administration. b. The CSF/blood ratios of [MnTBAP] over time in injured and sham control animals. The time courses of the ratios show stability and low penetration of BSB in both injured and sham control rats.