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. Author manuscript; available in PMC: 2015 Jan 10.
Published in final edited form as: Cent Nerv Syst Agents Med Chem. 2012 Jun;12(2):122–130. doi: 10.2174/187152412800792742

Fig. (2).

Fig. (2)

The time courses of [EUK-134] changes following administration. The animal experimental procedures were the same as in Fig. 1, and the HPLC analysis is described in Materials and Methods. EUK-134 (15 mg/kg) was administered (ip) immediately after SCI (25 g․cm). a. The time courses of [EUK-134] changes in blood and CSF samples from injured and sham control animals. A sharp decline in [EUK-134] is observed in blood. b. The CSF/blood ratios of [EUK-134] in injured and sham control rats, showing greater penetration of the BSB compared with MnTBAP in Fig. 1b in both injured and sham control animals.