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. Author manuscript; available in PMC: 2015 Jan 10.
Published in final edited form as: J Pharmacogenomics Pharmacoproteomics. 2014 Sep 30;5(4):1000141. doi: 10.4172/2153-0645.1000141

Figure 2. Schematic representation of the proposed mechanisms of oxidative cell damage during RSV infection.

Figure 2

RSV infection of airway epithelial cells leads to increased superoxide formation and increased H2O2 production, due to up regulation of SOD 2 expression and activity. RSV-induced inhibition of Nrf2 activation, due to proteasome-dependent degradation, causes a progressive decrease in the expression of a variety of AOEs involved in H2O2 detoxification leading to accumulation of highly reactive radicals, such as hydroxyl radical, and subsequent cellular damage (* autoxidation in presence of transition metals).