Table 2.
Mean (SD) of annualized whole-brain PBVC atrophy rates between manual-KN-BSI, STEPS-KN-BSI, pBSI1, pBSIγ, and gBSI for ADNI
| Manual-KN-BSI | STEPS-KN-BSI | pBSI1 | pBSIγ | gBSI | |
|---|---|---|---|---|---|
| 1.5 T | |||||
| Controls (N = 195) | 0.56 (0.60) | 0.55 (0.56) | 0.49 (0.51) | 0.34 (0.36) | 0.53 (0.56) |
| AD (N = 133) | 1.40 (0.77) | 1.35 (0.72) | 1.25 (0.65) | 0.88 (0.48) | 1.34 (0.69) |
| 3 T | |||||
| Controls (N = 39) | 0.45 (0.79) | 0.40 (0.73) | 0.39 (0.75) | 0.22 (0.51) | 0.39 (0.71) |
| AD (N = 24) | 1.26 (0.71) | 1.22 (0.70) | 1.24 (0.72) | 0.81 (0.47) | 1.20 (0.69) |
| Comparison | Difference in mean (95% CI), p-value |
|
|---|---|---|
| 1.5 T | 3T | |
| Manual-KN-BSI versus STEPS-KN-BSI | ||
| Controls | 0.008 (−0.009 to 0.025), 0.3 | 0.050 (−0.006 to 0.107), <0.1 |
| AD | 0.050 (0.024–0.076), <0.001 | 0.036 (−0.016 to 0.089), 0.16 |
| Manual-KN-BSI versus gBSI | ||
| Controls | 0.029 (0.011–0.047), <0.01 | 0.059 (0.001–0.117), <0.05 |
| AD | 0.060 (0.033–0.088), <0.001 | 0.059 (0.005–0.113), <0.05 |
| STEPS-KN-BSI versus gBSI | ||
| Controls | 0.021 (0.005–0.037), <0.01 | 0.008 (−0.002 to 0.019), 0.1 |
| AD | 0.010 (−0.005 to 0.025), 0.2 | 0.022 (0.011–0.033), <0.001 |
| pBSI1 versus gBSI | ||
| Controls | −0.042 (−0.052 to −0.031), <0.001 | 0.001 (−0.021 to 0.021), 0.99 |
| AD | −0.091 (−0.103 to −0.078), <0.001 | 0.031 (0.012–0.050), <0.005 |
| pBSIγ versus gBSI | ||
| Controls | −0.191 (−0.221 to −0.161), <0.001 | −0.172 (−0.248 to −0.096), <0.001 |
| AD | −0.454 (−0.493 to −0.415), <0.001 | −0.398 (−0.499 to −0.297), <0.001 |
Key: AD, Alzheimer's disease; ADNI, Alzheimer's Disease Neuroimaging Initiative; BSI, boundary shift integral; CI, confidence interval; gBSI, generalized boundary shift integral; PBVC, percentage brain volume change; SD, standard deviation.