Table 4.
Mean (SD) of hippocampal PBVC atrophy rates among STEPS-KN-BSI, pBSI1, pBSIγ, and gBSI
| STEPS-KN-BSI | pBSI1 | pBSIγ | gBSI | |
|---|---|---|---|---|
| 1.5 T | ||||
| Controls (N = 195) | 1.12 (2.20) | 0.69 (1.62) | 0.40 (1.25) | 0.87 (1.86) |
| AD (N = 133) | 4.88 (3.23) | 2.91 (2.23) | 1.63 (1.72) | 3.90 (2.54) |
| 3 T | ||||
| Controls (N = 39) | 0.35 (2.27) | 0.37 (2.30) | 0.21 (1.53) | 0.15 (1.86) |
| AD (N = 24) | 3.35 (3.08) | 3.34 (3.1) | 1.74 (2.35) | 2.61 (2.46) |
| Comparison | Difference in mean (95% CI), p-value |
|
|---|---|---|
| 1.5 T | 3T | |
| STEPS-KN-BSI versus gBSI | ||
| Controls | 0.249 (0.151–0.347), <0.001 | 0.207 (−0.378 to 0.452), <0.01 |
| AD | 0.988 (0.793–1.184), <0.001 | 0.737 (0.387–1.086), <0.001 |
| pBSI1 versus gBSI | ||
| Controls | −0.185 (−0.244 to −0.126), <0.001 | 0.228 (−0.026 to 0.482), <0.1 |
| AD | −0.987 (−1.099 to −0.875), <0.001 | 0.724 (0.363–1.086), <0.001 |
| pBSIγ versus gBSI | ||
| Controls | −0.469 (−0.581 to −0.357), <0.001 | −0.061 (−0.235 to 0.358), 0.679 |
| AD | −2.264 (−2.473 to −2.055), <0.001 | −0.874 (−1.282 to −0.465), <0.001 |
Key: AD, Alzheimer's disease; BSI, boundary shift integral; CI, confidence interval; gBSI, generalized boundary shift integral; PBVC, percentage brain volume change; SD, standard deviation.