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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Cancer Res. 2014 Apr 7;74(11):3020–3030. doi: 10.1158/0008-5472.CAN-13-3276

Figure 1. Prothrombin supports colitis-associated adenoma formation.

Figure 1

(A) Quantitation of the total number of adenomas formed per animal after AOM/DSS challenge. Note that mice with a genetically imposed diminution in prothrombin levels to ~50% of normal (fII+/−) developed significantly fewer adenomas. (Horizontal bars represent median values.) Shown are representative H&E stained sections of adenoma tissue harvested from WT mice (B) and fII+/−mice (C). The high-powered insets show the loss of epithelial cell polarity, nuclear pleomorphism, cell piling (*) and frequent mitotic figures (arrowheads) typical of adenomas. (D) A section of unchallenged colonic tissue cut in the same plane is shown for comparison. Size bars represent 20 μm or 10 μm (insets).