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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Cancer Res. 2014 Apr 7;74(11):3020–3030. doi: 10.1158/0008-5472.CAN-13-3276

Figure 4. Prothrombin deficiency does not significantly alter the clinical severity or mucosal damage associated with multicourse DSS challenge.

Figure 4

(A) The waxing and waning weight loss associated with multicourse DSS challenge is similar in WT and fII+/− mice (n = 9 per group). (B) Shown are photomicrographs of representative H&E stained sections of colonic tissue harvested from WT and fII+/− mice at the end of the second course of DSS (i.e. day 28). Note that DSS-challenged colons from mice of both genotypes revealed similar degrees of significant mucosal ulcerations (arrows) and inflammatory edema (*). Size bars represent 50 μm. (C) Detailed microscopic analyses using a multiparameter histopathological scoring system confirmed that DSS-challenged colons harvested from WT mice (n = 8) and fII+/− mice (n = 9) showed similar degrees of disease severity for each parameter analyzed. (P values were not significant for each comparison between DSS-challenged WT and fII+/− cohorts.)