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. Author manuscript; available in PMC: 2015 Jan 10.
Published in final edited form as: Neurosurgery. 2012 Jan;70(1):178–187. doi: 10.1227/NEU.0b013e31822ec2b0

Figure 3. Sildenafil attenuates vasospasm following SAH.

Figure 3

Mice underwent SAH or sham operation. Treatment with sildenafil (Sil) (0.7, 2 and 5 mg/kg P.O. BID) or vehicle (Veh) was initiated 2 hours later. On post-surgery day 3, mice were perfused with gelatin/india ink. A. Representative images of gelatin/India ink-casted cerebral vessels. Vasospasm of the MCA was evident in SAH mice compared with sham-operated mice; sildenafil attenuates this SAH-induced vasospasm. Scale bar: 200 µm. Abbreviations: ACA=anterior cerebral artery; ICA=internal carotid artery. B. Vessel caliber in the proximal MCA ipsilateral to suture perforation was determined. Data represent the mean±S.E.M. *P<0.05 vs. Sham:vehicle, #p<0.05 vs. SAH:vehicle. Data were analyzed by ANOVA followed by Newman-Keuls multiple comparison test.