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Pro-inflammatory and anti-inflammatory cytokine release from endotoxin (LPS)-stimulated polymorphonuclear leukocytes of the newborn over 18 hours (n=7, mean±SE): effects of pretreatment with equimolar (10−8 M) doses of interleukin-10 and dexamethasone. Panel A shows tumor necrosis factor release, * different from LPS alone, p<0.001. Panel B shows interleukin-1β release, ** different from LPS alone, p<0.01. Panel C shows interleukin-1 receptor antagonist release.
