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Model of oral streptococcus- and NO2-mediated inhibition of P. aeruginosa. During polymicrobial infections when nitrite is present, H2O2-producing oral streptococci can induce the production of the antimicrobial peroxynitrite, which may be transported by a P. aeruginosa ABC transporter permease. Loss of the permease results in polyamine-mediated resistance to peroxynitrite or decreased outer membrane permeability of peroxynitrite.
