TABLE 1.
Survival of mice given an Stx2-neutralizing VNA treatment or a placebo intraperitoneally 4 h before challenge with Stx2
| Treatmenta | Dose (vp/mouse) | No. of surviving mice (% survival)b | Mean time (days) to death/euthanasia (± SD)c | Mean serum VNA concn (μg/ml) (range)d |
|---|---|---|---|---|
| Ad/VNA-Stx | 1 × 1010 | 10 (100) | 7.0 (±0.0) A | 2.55 (0.5–6.0) |
| Placebo | PBS | 0 (0) | 2.4 (±0.5) B |
a
There were 10 mice in each group. Mice in the Ad/VNA-Stx group were given an Stx2-neutralizing VNA treatment intraperitoneally 4 h before Stx2 challenge. Mice in the placebo group received PBS only.
b
Mice in the placebo group either died overnight or were euthanized due to severe illness. All mice in the Ad/VNA-Stx group survived and were euthanized after 7 days.
c
Different capital letters following survival times indicate statistically significant differences (P < 0.001) between those treatment groups.
d
Estimated concentration of VNA in mouse serum at the time of euthanasia.