TABLE 2.
Survival of piglets given either a placebo or an Stx2-neutralizing VNA treatment intramuscularly 18 h before oral challenge with 1 × 1010 CFU of STEC 86-24
| Treatmenta | Dose (vp/kg) | No. of surviving piglets (% survival)b | Mean time (days) to death/euthanasia (± SD)c | Mean serum VNA concn (μg/ml) (range)d |
|---|---|---|---|---|
| Ad/VNA-Stx | 1 × 1012 | 5 (100) | 12 (±0.0) A | 0.05 (0.025–0.1) |
| Placebo | PBS | 0 (0) | 5.0 (±2.0) B |
a
There were 5 piglets per group.
b
Piglets in the placebo group either died overnight or were euthanized due to severe illness.
c
All piglets in the Ad/VNA-Stx group were euthanized after 12 days. Different capital letters following survival times indicate statistically significant differences (P < 0.001) between those treatment groups.
d
Estimated concentration of VNA in piglet serum at the time of euthanasia.