FIG 4.
Granuloma polarization ratio (RGP) and TNF and IL-10 dynamics. (A) Granuloma polarization ratios (RGP) over time for both contained granulomas (n = 377) and disseminated in silico granulomas (n = 1,119). For ease of illustration, error bars are not shown. The time points between day 70 and day 130 as well as after day 170 show strong statistically significant differences between the two trajectories (*, P < 1e-2; **, P < 1e-3; ***, P < 1e-4). (B) Average trajectories of the ratios between the numbers of TNF and IL-10 molecules on the 2-mm-by-2-mm virtual environment between the contained and disseminated granuloma scenarios (as shown in Fig. 3).