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. 2014 Dec 16;83(1):324–338. doi: 10.1128/IAI.02494-14

TABLE 1.

List of parameters varied in the uncertainty and sensitivity analysisa

Parameter Parameter description Value Reference(s) or source
τNFκB (no./cell) Cell surface sTNF/TNFR1 threshold for TNF-induced NFκB activation 40–60 [50] 76
kNFκB [(no./cell)−1 s−1] Rate constant for TNF-induced NFκB activation in macrophages 5e-6–1e-5 [5e5] 76
τSTAT3-IL-10 (no./cell) Cell surface sIL-10/IL-10R threshold for IL-10-induced STAT3 10–20 [15] Estimated
kNFκBSTAT3IL-10 [(no./cell)−1 s−1] Rate constant for IL-10-induced STAT3 activation in macrophages 0.00075–0.0016 [0.001] Estimated
SynthIL-10-MI (no./cell · s) Full-synthesis rate of soluble IL-10 by Mi 0.06–0.22 [0.17] 84, 85
SynthIL-10-MA (no./cell · s) Full-synthesis rate of soluble IL-10 by Ma 0.04–0.65 [0.45] 86, 87
αIntMtb (days) Doubling time for intracellular M. tuberculosis 1–2 [1.5] 83
αExtMtb (days) Doubling time for extracellular M. tuberculosis 2–5 [4] 83
probKillExtMtbM0 Probability of M0 killing extracellular bacteria 0.05–0.25 [0.15] Estimated
probKillExtMtb Probability of non-M0 killing extracellular bacteria 0.75–1 [0.8] Estimated
probKillIntMtb Probability of non-M0 killing intracellular bacteria 0.001–1 [0.5] Estimated
βSTAT1 (min−1) Rate of signal activation strength of STAT1 1–25 [13] 88, 89
βSTAT3 (min−1) Rate of signal activation strength of STAT3 1–25 [13] 90–93
βNFκB (min−1) Rate of signal activation strength of NFκB 1–25 [13] 88, 90, 94
δSTAT1 (min−1) Rate of signal degradation/inhibition of STAT1, which controls the length of time the STAT1 signal is turned on (i.e., the signal activation interval) 0.0001–0.1 [0.0126] 88, 89
δSTAT3 (min−1) Rate of signal degradation/inhibition of STAT3, which controls the length of time the STAT3 signal is turned on (i.e., the signal activation interval) 0.0001–0.1 [0.0145] 90–93
δNFκB (min−1) Rate of signal degradation/inhibition of NFκB, which controls the length of time the NFκB signal is turned on (i.e., the signal activation interval) 0.0001–0.1 [0.0197] 88, 90, 94
τAgeTransition Normalized macrophage polarization ratio threshold for transitioning to a shorter life span 0.7–0.9 [0.85] Estimated
timeRecEnabled (days) Days when effector T cells recruitment is enabled 20–30 [21] Estimated
probStat1Tγ Probability of macrophage STAT1 activation induced by IFN-γ-producing T cells 0.001–0.1 [0.05] Estimated
a

The rest of the parameter values used to generate the in silico granulomas shown in Fig. 3 can be found in reference 22. The containment parameters are indicated in square brackets. sTNF, soluble tumor necrosis factor; TNFR1, tumor necrosis factor receptor 1.