FIG 1.
Diverse N. meningitidis strains can colonize CEACAM1-humanized mice. (A) Cohorts of CEACAM1-humanized mice (gray circles) or wild-type mice (white circles) were intranasally inoculated with 105 CFU of N. meningitidis. Strain designation and type are indicated above individual graphs. Each circle represents the number of viable N. meningitidis bacteria recovered from nasal samples enumerated 3 days postinfection. Group sizes and percentages of colonized mice within each cohort are indicated below each graph. Note that data obtained using strains 90/18311, 38VI, and 196/87 are identical to those in Fig. 4c (in the context of which the data were generated) but are shown here as well for qualitative comparison to the other strains. (B) Western blotting of lysates of N. meningitidis strains to monitor expression of Opa protein.