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. 2014 Oct 6;53(48):13054–13058. doi: 10.1002/anie.201405664

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© 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Examples of lmwPEGs adopting a ring-shaped conformation in a variety of deposited crystal structures. Three examples of PDB entries containing ring-shaped lmwPEGs: a) Pin1R14A (2ITK), b) human myosin light chain kinase (2X4F), and c) dTMP kinase (2PLR). Different protein chains are colored in gray, green, and purple. Chains within an asymmetric unit are capitalized, while crystallographic equivalents are marked with an asterisk (*). d) Top: PEG200 in its linear conformation. PEG200 was bound by 2PLR. Bottom: 18-crown-6 ether is a circular molecule, which is strikingly similar to ring-shaped PEG200. Molecular weights and formulas are taken from Pubchem (CID 62551 for PEG200, and CID 28557 for 18-crown-6).