Skip to main content
. Author manuscript; available in PMC: 2015 Jan 10.
Published in final edited form as: Curr Colorectal Cancer Rep. 2013 Dec;9(4):350–357. doi: 10.1007/s11888-013-0190-5

Figure 1. ROS dependent downregulation of Sp proteins and other oncogenic factors.

Figure 1

Treatment of colon cancer cells with ROS inducing drugs disrupt miR-ZBTB interaction to induce Sp repressors ZBTB10 and or ZBTB4 that act as transcriptional repressors on GC-rich cis elements [41, 42].