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. 2014 Dec 4;15(1):1065. doi: 10.1186/1471-2164-15-1065

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© Silva et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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2D nanoUPLC HDMSE analysis showing: (A) Dynamic range of the method based on protein abundance estimates, data points derived from LC-HDMS ^E analysis. (B and C) Proteins that were significantly differentially-regulated during NO exposure. The distribution of identified proteins with p < 0.05, and differentially-regulated proteins with an I:C log₂ ratio < 1.2 in relation to the number of peptides identified for each protein. (B) Proteins with p < 0.05 and an I:C log₂ ratio < 1.2. (C) Proteins with p < 0.05 and an I:C log₂ ratio > 1.2.