TABLE II.
Relationship of epithelial ST2L mRNA to markers of TH2-like inflammation
TH2-like marker group | P value | ||||
---|---|---|---|---|---|
Low | High | ||||
n | Relative ST2L mRNA, Geometric mean (95% CI) | n | Relative ST2L mRNA, Geometric mean (95% CI) | ||
Blood eosinophils | 50 | 0.05 (0.03–0.1) | 27 | 0.29 (0.14–0.62) | .001* |
BALF eosinophils | 38 | 0.08 (0.04–0.17) | 33 | 0.12 (0.06–0.24) | .45 |
Sputum eosinophils | 32 | 0.1 (0.05–0.21) | 18 | 0.05 (0.02–0.12) | .21 |
Exhaled nitric oxide | 43 | 0.05 (0.03–0.1) | 33 | 0.21 (0.10–0.42) | .003* |
CLCA1 epithelial mRNA | 33 | 0.04 (0.02–0.07) | 39 | 0.32 (0.16–0.62) | <.0001* |
Eotaxin-3 epithelial mRNA | 35 | 0.05 (0.03–0.09) | 41 | 0.24 (0.12–0.47) | .001* |
Blood eosinophils cutoff was ≥300 cells/mm3.
Sputum eosinophils cutoff was ≥2%.
BALF eosinophils, exhaled nitric oxide, CLCA1 mRNA and Eotaxin-3 mRNA were divided based on a median split.
BALF, Bronchoalveolar lavage fluid.