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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Gene Ther. 2014 Sep 18;22(1):87–95. doi: 10.1038/gt.2014.85

Figure 1. Efficacy of intravenous injection of HDAd expressing monkey LDLR in heterozygous LDLR-deficient rhesus monkeys.

Figure 1

Four heterozygous LDLR-deficient monkeys were treated with a single intravenous injection of saline (#8796), empty vector at a dose of 0.8×1012 vp/kg (#9908), or HDAd-LDLR at a dose of 1.1×1012 vp/kg (#7139) or 5×1012 vp/kg (#13090). Baseline cholesterol levels were 18.0 mmol/l (696 mg/dl) in monkey #8796, 9.5 mmol/l (368 mg/dl) in monkey #9908, 8.0 mmol/l (308 mg/dl) in monkey #7139 and 15.0 mmol/l (578 mg/dl) in monkey #13090, respectively. The broken line shows pretreatment cholesterol levels.