Table 2.

Effects of gene therapy on plasma cholesterol and LDL metabolism.

#19498	Pre-treatment	Post-treatment
Plasma cholesterol (mmol/l)	7.60	4.75
LDL cholesterol (mmol/l)	5.90	3.10
HDL cholesterol (mmol/l)	1.75	1.75
Relative LDLR mRNA expression	1.37	14.32
LDL apoB FCR (pool/day)	0.230	0.410
LDL apoB production rate (mg/kg/day)	11.28	11.52
#19269
Plasma cholesterol (mmol/l)	9.60	4.50
LDL cholesterol (mmol/l)	6.80	2.25
HDL cholesterol (mmol/l)	2.75	2.30
Relative LDLR mRNA expression	0.47	12.64
LDL apoB FCR (pool/day)	0.276	0.415
LDL apoB production rate (mg/kg/day)	10.32	10.80

The pre-treatment studies were done 10 days before gene therapy and the post-treatment studies were performed 79 days after gene transfer. Both were heterozygous LDLR+/− monkeys. #19498 was injected by 2×10¹² vp/kg HDAd-LDLR after balloon was deflated, whereas #19269 was treated by 1×10¹² vp/kg while balloon was inflated.