Table 2.
#19498 | Pre-treatment | Post-treatment |
---|---|---|
Plasma cholesterol (mmol/l) | 7.60 | 4.75 |
LDL cholesterol (mmol/l) | 5.90 | 3.10 |
HDL cholesterol (mmol/l) | 1.75 | 1.75 |
Relative LDLR mRNA expression | 1.37 | 14.32 |
LDL apoB FCR (pool/day) | 0.230 | 0.410 |
LDL apoB production rate (mg/kg/day) | 11.28 | 11.52 |
#19269 | ||
Plasma cholesterol (mmol/l) | 9.60 | 4.50 |
LDL cholesterol (mmol/l) | 6.80 | 2.25 |
HDL cholesterol (mmol/l) | 2.75 | 2.30 |
Relative LDLR mRNA expression | 0.47 | 12.64 |
LDL apoB FCR (pool/day) | 0.276 | 0.415 |
LDL apoB production rate (mg/kg/day) | 10.32 | 10.80 |
The pre-treatment studies were done 10 days before gene therapy and the post-treatment studies were performed 79 days after gene transfer. Both were heterozygous LDLR+/− monkeys. #19498 was injected by 2×1012 vp/kg HDAd-LDLR after balloon was deflated, whereas #19269 was treated by 1×1012 vp/kg while balloon was inflated.