Table 3.
Comparison of parental and F1 phenotypes after 21 days of high salt intake
| Group | n= | MAP (mmHg) | UAlb (mg/day) | %Glom score of 4 | Casting (%) | UNaE (mEq/day) | BW at surgery(g) | Final BW (g) | Kidney/ BW (g/g*1000) |
|---|---|---|---|---|---|---|---|---|---|
| SS/McwC0.4 | 23 | 154±5* | 170±18* | 7.3±0.8* | 17.0±0.7* | 11.0±0.7 | 178±4.8 | 357±12 | 4.45±0.40 |
| SS/McwC0.4 >SS/McwC0.4 | 8 | 157 ±6† | 204±16† | 10.5±2.8† | 21.7± 3.3† | 11.6± 0.4 | 145±3.9 | 309±6.8 | 5.70±0.18† |
| SS/CrlG0.75 >SS/McwC0.4 | 21 | 166 ±5‡ | 187±26‡ | 10.3±1.9‡ | 18.9± 1.7‡ | 10.2± 0.8 | 168±4.1 | 318±6.3 | 5.71±0.25‡ |
| SS/CrlG0.75 | 13 | 116 ±2 | 23±3 | 1.1±0.7 | 3.5±0.8 | 13.3± 0.7 | 201±4.8 | 353±5.0 | 3.93±0.07 |
| SS/McwC0.4 >SS/CrlG0.75 | 14 | 138 ±4 | 92±13 | 0.9±0.3 | 4.9±0.6 | 12.5± 0.4 | 157±2.6 | 331±3.7 | 4.56±0.11 |
| SS/CrlG0.75 >SS/CrlG0.75 | 14 | 141 ±4 | 96±17 | 1.4±0.8 | 7.2±2.5 | 12.0± 0.6 | 159±4.7 | 326±5.6 | 4.86±0.15 |
| SS/CrlC0.4 | 15 | 153 ±7 | 143±23 | ND | ND | 11.3± 0.9 | 173±4.8 | 353±17 | 5.13±0.39 |
*
significantly increased compared to SS/Crl, p<0.05;
#
significantly increased compared to SS/McwC0.4>SS/CrlG0.75, p<0.05;
‡
significantly increased compared to SS/CrlG0.75>SS/CrlG0.75, p<0.05.
§
note animals in the SS/Crl parental group were maintained on the G0.75 diet until 6–7 weeks of age, whereas the SS/Mcw and all F1 group animals were all weaned to the C0.4 diet (see Figure 1). BW: body weight. BW at surgery was measured at ~6 weeks of age, before the 21 days of high salt intake.