Table 1.
Differential diagnostic markers of small-blue- round-cell tumors in lung
| IHC markers | CD99 | CD56 | Vim | TTF | Syn | Chr | CD34 | LCA (CD45) | CD10 | CD15 | CK7 | AE1/AE3 | CK(HMW) | Calret | h-Cal | Desmin | SMA | HBME-1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tumor types | ||||||||||||||||||
| PNET | ++ | +/- | + | - | +/- | - | - | - | - | - | - | +/- | - | - | - | - | - | - |
| Desmoplastic small round cell tumor of lung | - | - | ++ | - | - | - | - | - | - | - | - | ++ | - | - | - | - | - | - |
| Small cell carcinoma of the lung | - | + | - | ++ | + | + | - | - | - | - | - | ++ | - | + | - | - | - | - |
| Lung carcinoid | - | - | - | + | ++ | ++ | - | - | - | - | - | ++ | - | - | - | - | - | - |
| Metastasis of small cell carcinomas of other origin | - | +/- | - | + | - | - | - | - | - | - | + | + | + | - | - | - | - | - |
| Pulmonary rhabdomyosarcoma | - | - | - | - | - | - | - | - | - | - | - | - | - | - | + | + | - | - |
| NHL | +/- | - | - | - | - | - | - | ++ | + | + | - | - | - | - | - | - | - | - |
Calret, calretinin; Chr, chromogranin; CK7, cytokeratin 7; CK(HMW), high molecular weight cytokeratin; HBME-1 – mesothelial cell marker; h-Cal, h-caldesmon; IHC, immunohistochemistry; LCA, leukocyte common antigen; NHL, non-Hodgkin’s lymphoma; PNET, primitive neoroectodermal tumor; SMA, smooth muscle actin; Syn, Synaphtophysin; TTF, thyroid transcription factor; Vim, vimentin.