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. 2014 Nov 18;15(1):988. doi: 10.1186/1471-2164-15-988

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© Milon et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Genome viewer snapshot shows domains of open and closed chromatin detected by GCSDI. An approximately 250 kbp window demonstrates the relationship of differential GCSDI signal, 2CM, and 3CM models to the genes, predicted 9 chromatin states, and lamina-associated domains (LADs). DNase I hypersensitive site assay signal (DHS) is shown for comparison. Open chromatin domains are shown in green and closed – in red in 2CM and 3CM traces. Discrepancies between chromatin structure predictions (repressed) and chromatin compactness (open) are outlined by arrows.