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. 2014 Nov 18;15(1):988. doi: 10.1186/1471-2164-15-988

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© Milon et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Relationship between open and closed chromatin and gene structure. Proportions of open and closed chromatin detected by 2CM are shown for intergenic spacers and active or silent genes (A) and for structural elements of active and silent gene (B). Analysis of relationship between chromatin structure and the size of gene (C) and intron (D) shows that proportion of open chromatin diminishes as the gene and intron size increases for both active and silent genes. (E), Distribution of poen and closed chromatin along large (>10 kbp) active gene introns.