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. 2014 Nov 18;15(1):988. doi: 10.1186/1471-2164-15-988

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© Milon et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Chromatin compactness versus gene expression. Representation of open, closed, and neutral chromatin is shown for structural elements of genes that differ in their expression status and promoter chromatin configuration (A). (B), RNAseq reads per kilobase pair of gene per million (RPKM) are shown as surrogate expression levels for silent and active genes with open or closed promoters. (C), expression breadth metric tau[20] of testis-biased genes from gene clusters embedded in open versus closed chromatin domains. Note that if tau value is higher, the expression breadth is lower and thus tissue-specificity of gene expression is increased.