Table 1.
Correlation between proteins expression and clinicopathological characteristics of patients with MB
| Clinicopathological characteristics | DJ-1 expression a | p-Akt expression a | Proliferative activity (Ki-67 value) b | ||
|---|---|---|---|---|---|
| Low (n = 34) | High (n = 32) | Low (n = 29) | High (n = 37) | ||
| Age, year | |||||
| ≤3 (n = 19) | 13 | 6 | 7 | 12 | 25.28 ± 7.59 |
| >3 (n = 47) | 21 | 26 | 22 | 25 | 26.77 ± 8.74 |
| P value | 0.030 | 0.275 | 0.519 | ||
| Sex | |||||
| Male (n = 43) | 23 | 20 | 18 | 25 | 25.80 ± 7.31 |
| Female (n = 23) | 11 | 12 | 11 | 12 | 27.36 ± 10.23 |
| P value | 0.619 | 0.527 | 0.475 | ||
| WHO histological subtype c | |||||
| Classic (n = 50) | 23 | 27 | 22 | 28 | 25.17 ± 7.75 |
| Desmoplastic (n = 14) | 11 | 3 | 7 | 7 | 30.03 ± 9.89 |
| P value | 0.003 | 0.536 | 0.055 | ||
| Tumor location | |||||
| Fourth ventricle (n = 29) | 16 | 13 | 10 | 19 | 26.65 ± 8.51 |
| Outside fourth ventricle (n = 37) | 18 | 19 | 19 | 18 | 26.11 ± 8.42 |
| P value | 0.556 | 0.065 | 0.795 | ||
| Residual tumor size | |||||
| ≤1.5 cm2 (n = 54) | 29 | 25 | 24 | 30 | 25.75 ± 8.14 |
| >1.5 cm2 (n = 12) | 5 | 7 | 5 | 7 | 29.04 ± 9.38 |
| P value | 0.221 | 0.829 | 0.222 | ||
| Metastatic status | |||||
| M0 (n = 12) | 5 | 7 | 3 | 9 | 28.20 ± 7.39 |
| M1 (n = 54) | 29 | 25 | 26 | 28 | 25.93 ± 8.61 |
| P value | 0.221 | 0.007 | 0.401 | ||
| Tumor risk | |||||
| Standard (n = 6) | 2 | 4 | 1 | 5 | 30.50 ± 9.58 |
| High (n = 60) | 32 | 28 | 28 | 32 | 25.93 ± 8.25 |
| P value | 0.031 | 0.010 | 0.201 | ||
| Differentiation level | |||||
| Undifferentiated (n = 39) | 14 | 25 | 13 | 26 | 27.28 ± 8.82 |
| Differentiated (n = 27) | 20 | 7 | 16 | 11 | 25.00 ± 7.71 |
| P value | 0.001 | 0.007 | 0.281 | ||
| DJ-1 expression | |||||
| Low (n = 34) | 20 | 14 | 23.33 ± 6.22 | ||
| High (n = 32) | 9 | 23 | 29.54 ± 9.28 | ||
| P value | 0.001 | 0.002 | |||
| p-Akt expression | |||||
| Low (n = 29) | 20 | 9 | 25.13 ± 6.92 | ||
| High (n = 37) | 14 | 23 | 27.29 ± 9.38 | ||
| P value | 0.001 | 0.303 | |||
aχ2 test.
bOne-way ANOVA.
cWe did not carry out statistical analysis for the large cell/anaplastic variant and medullomyoblastoma because there were insufficient numbers of cases.