Table 3.
Univariate analysis of factors affecting five-year survival after pancreatectomy for pancreatic adenocarcinoma
| Characteristics | Short-term survivors (n = 129) | Five-year survivors (n = 18) | P value |
|---|---|---|---|
| Gender | |||
| Male | 72 | 13 | 0.21 |
| Female | 57 | 5 | |
| Age (years) | |||
| Median (range) | 67 (33-85) | 65 (46-76) | 0.28 |
| Tumor location | |||
| Head | 85 | 12 | 1 |
| Body/tail | 44 | 6 | |
| Tumor size (cm) | |||
| Median (range) | 3.5 (1.2-18) | 3.2 (1.2-5.5) | 0.52 |
| ≤2 cm | 14 | 5 | 0.06 |
| >2 cm | 115 | 13 | |
| Histologic differentiation | |||
| Grade 1-2 | 102 | 11 | 0.13 |
| Grade 3-4 | 27 | 7 | |
| T classification | |||
| T1-T2 | 14 | 3 | 0.44 |
| T3-T4 | 115 | 15 | |
| N classification | |||
| N0 | 49 | 10 | 0.2 |
| N1 | 80 | 8 | |
| Number of resected lymph nodes | |||
| Median (range) | 25 (2100) | 17 (258) | 0.51 |
| Number of lymph node metastasis | |||
| ≤2 | 95 | 18 | 0.01 |
| ≥3 | 34 | 0 | |
| CA19-9 level (U/mL) | |||
| Median (range) | 172 (223009) | 30.5 (23221) | 0.02 |
| ≤40 | 34 | 12 | 0 |
| >40 | 94 | 6 | |
| Resection margin | |||
| R0 | 58 | 14 | 0.01 |
| R1-R2 | 71 | 4 | |
| Adjuvant therapy | |||
| Yes | 19 | 1 | 0.47 |
| No | 110 | 17 | |
| Serosal invasion | |||
| Present | 81 | 10 | 0.61 |
| Absent | 48 | 8 | |
| Retroperitoneal invasion | |||
| Present | 91 | 11 | 0.58 |
| Absent | 36 | 6 | |
| Intrapancreatic common bile duct invasion | |||
| Present | 61 | 7 | 0.62 |
| Absent | 68 | 11 | |
| Lymphatic permeation | |||
| Present | 113 | 16 | 1 |
| Absent | 16 | 2 | |
| Vascular permeation | |||
| Present | 63 | 8 | 0.8 |
| Absent | 66 | 10 | |
| Intrapancreatic nerve invasion | |||
| Present | 118 | 13 | 0.03 |
| Absent | 13 | 5 | |
| Portal vein resection | |||
| Present | 31 | 2 | 0.37 |
| Absent | 98 | 16 | |
| Intraoperative radiation therapy | |||
| Present | 11 | 3 | 0.38 |
| Absent | 118 | 15 |