Table 3.
Treatment | Dose (mg/kg) | Reaction time (sec) | |||
---|---|---|---|---|---|
0 min | 30 min | 60 min | 90 min | ||
Control (Saline water) | 10 | 2.21 ± 0.10 | 2.5 ± 0.18 | 2.9 ± 0.37 | 2.39 ± 0.19 |
Nalbuphine | 10 | 2.27 ± 0.15 | 6.05 ± 0.49** | 9.23 ± 0.40* | 11.93 ± 1.04** |
VTA | 200 | 2.87 ± 0.40 | 3.46 ± 0.51* | 5.08 ± 0.67 | 6.38 ± 0.61 |
VTA | 400 | 2.79 ± 0.34 | 4.95 ± 0.34 | 6.38 ± 0.55* | 9.91 ± 0.88** |
VTM | 200 | 2.16 ± 0.22 | 2.61 ± 0.10* | 5.12 ± 1.66* | 4.40 ± 0.53 |
VTM | 400 | 1.8 ± 0.32 | 6.2 ± 4.10* | 5.43 ± 0.18* | 8.15 ± 1.86* |
Values are expressed as mean ± SEM; (n = 5). *p < 0.05, **p < 0.01 as compared with control. Data were processed with Dunnet’s test for multiple comparisons, GraphPad Prism for Windows, Version 6.0. VTA = V. tessellata aqueous extract, VTM = V. tessellata methanol extract.