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. 2014 Dec 4;14:916. doi: 10.1186/1471-2407-14-916

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© Stimmer et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Gb3 expression in primary breast tumors and lymph node metastases. A: Estrogen receptor and Gb3 expression in primary breast tumors. Note: Gb3 positivity (Gb3 + group) is correlated with estrogen receptor expression. **: p ≤ 0.01, ER: estrogen receptor. B: Presence of axillary lymph node metastases in patients with and without Gb3 expression in primary breast cancer. Note a higher number of patients with lymph node metastases in the Gb3 negative group. *: p ≤ 0.03, LN: lymph node. C: Relative numbers of Gb3 expressing cells. D: Change in Gb3 expression between primary and metastatic tumors. Note: 40% of patients showed relative increase, whereas 50% had no change, and 10% lost Gb3 expression in the lymph node metastases compared to the primary tumor.