. 2014 Nov 27;14:456. doi: 10.1186/1472-6882-14-456

Table 4.

Cytotoxicity of extracts and fractions from S. spinosa , and their selectivity index (SI)

Samples	Cytotoxicity (LC50, μg/ml)	Selectivity index (SI) ^*
		C.a	C.A	A.f	C.n	S.a	B.c	E.f	E.c
Extracts
AcetE	30.56 ± 0.00^a	< 0.02	< 0.02	0.02	0.05	0.19	0.1	0.19	0.04^**
MetE	361.48 ± 0.02^b	< 0.30	< 0.30	0.3	0.57	< 0.30	< 0.30	< 0.30	0.57
DcmMetE	38.38 ± 0.00^c	< 0.03	< 0.03	0.03	0.24	0.06	< 0.03	0.06	0.06
AlkE	141. 54 ± 0.00^d	< 0.11	< 0.11	< 0.11	0.44	0.88	0.11	0.44	0.20^**
Fractions
HexF	71.28 ± 0.01^e	0.06	0.11	< 0.06	0.09^**	0.9	0.08^**	0.22	0.11^**
ChlF	67.20 ± 0.00^f	0.42	0.11	0.84	0.09^**	0.84	0.11	0.42	0.28^**
EtAcF	479.44 ± 0.07^g	0.76	3	6	0.61^**	0.76	0.51^**	0.20^**	0.68^**
nBuF	50.49 ± 0.01^h	< 0.04	< 0.04	0.04	0.08^**	0.42^**	0.08	0.04	0.08
WatF	689.39 ± 0.00ⁱ	< 0.55	< 0.55	0.55	0.73^**	< 0.55	< 0.55	< 0.55	0.55
Control
Dox	2.59 ± 0.00

AcetE: Acetone Extract, MetE: Methanol extract DcmMetE: Dichloromethane/methanol extract, AlkE: Alkaloids extract, HexF: n-hexane fraction, ChlF: Chloroform fraction, EtAcF: Ethyl acetate fraction, nBuF: n-Butanol fraction, WatF: Water fraction, Dox: Doxorubicin with LC₅₀ in μM, NT: not tested, ^*SI = LC₅₀ /MIC, ^**SI obtained from average MIC. ) C.^a Candida albicans (Isolate); C.A: Candida albicans (ATCC strain); C.n: Cryptococcus neoformans; A.f: Aspergillus fumigatus E.c: Escherichia coli, E.f: Enterococcus faecalis, S.a: Staphylococcus aureus, B.c: Bacillus cereus. Values with different letters are significantly different at p < 0.05.