Table 3.
Demographic, diagnostic and hemodynamic data of the different patient cohorts.
| DPG ≥7 (n=62) | DPG <7 (n=407) | p-value† | No PH (n=650) | p-value‡ | |
|---|---|---|---|---|---|
| Demographics | |||||
| Age (years) | 49.3 [39.5–58.5] | 49.0 [36.7–60.9] | 0.98 | 46.7 [35.4–57.4] | 0.11 |
| Height (m) | 1.75 [1.65–1.80] | 1.73 [1.68–1.83] | 0.08 | 1.73 [1.35–1.98] | 0.21 |
| Weight (kg) | 83.8 [68.7–98.0] | 79.0 [65.9–91.8] | 0.15 | 76.8 [63.6–89.0] | 0.017 |
| Body Mass Index (kg/m2) | 27.3 [22.9–30.7] | 26.1 [22.9–30.9] | 0.47 | 25.5 [22.4–29.1] | 0.021 |
| Female Gender | 18 (29) | 149 (37) | 0.31* | 274 (42.1) | 0.045* |
| Race | |||||
| Black | 29 (47) | 140 (35) | 208 (32) | ||
| Caucasian | 32 (52) | 257 (63) | 425 (66) | ||
| Other | 1 (2) | 8 (2) | 0.18* | 12 (2) | 0.24* |
| Diagnosis | |||||
| Idiopathic | 27 (44) | 205 (50) | 326 (50) | ||
| Coronary artery disease | 5 (8) | 41 (10) | 36 (6) | ||
| Myocarditis | 4 (6) | 28 (7) | 76 (12) | ||
| Toxic/Metabolic | 5 (8) | 19 (5) | 28 (4) | ||
| Other | 21 (34) | 114 (28) | 0.63* | 184 (28) | 0.033* |
| Hemodynamics | |||||
| Heart rate (beats per minute) | 94 [82–107] | 93 [80–106] | 0.69 | 84 [72–95] | <0.001 |
| Systemic Blood Pressure | |||||
| Systolic (mmHg) | 128 [105–151] | 117 [104–138] | 0.04 | 120 [107–137] | 0.09 |
| Diastolic (mmHg) | 82 [72.0–90.3] | 77.5 [68.0–86.0] | 0.01 | 73 [67.0–81.2] | <0.001 |
| Mean (mmHg) | 98.2 [87.2–111.3] | 90.7 [80.7–105.4] | 0.01 | 89.5 [81.0–100.0] | 0.001 |
| Systemic Vascular Resistance (Wood units) | 22.6 [16.3–30.1] | 20.6 [16.4–27.3] | 0.52 | 19.1 [15.2–23.1] | <0.001 |
| Left Ventricular Stroke Work Index (mmHg ml/m2) | 1521 [1208–2236] | 1342 [1033–1870] | 0.035 | 2316 [1766–3041] | <0.001 |
| Right Atrial Pressure (mmHg) | 13 [8.8–17.0] | 10.0 [7.0–15.0] | 0.048 | 4 [2.0–6.0] | <0.001 |
| Pulmonary Artery Pressures | |||||
| Systolic (mmHg) | 60.0 [51.5–70.0] | 52.0 [45.0–59.0] | <0.001 | 28 [23.0–33.0] | <0.001 |
| Diastolic (mmHg) | 31.5 [28.0–36.5] | 26.0 [22.0–30.0] | <0.001 | 11.5 [8.0–15.0] | <0.001 |
| Mean (mmHg) | 40.2 [36.7–48.8] | 34.0 [29.7–40.0] | <0.001 | 17 [13.7–10.7] | <0.001 |
| Pulmonary Capillary Wedge Pressure (mmHg) | 22.0 [18.0–27.0] | 26.0 [22.0–30.0] | <0.001 | 10 [7.0–13.0] | <0.001 |
| Cardiac Index (L/min/m2) | 1.90 [1.55–2.5] | 1.93 [1.60–2.35] | 0.96 | 2.4 [2.0–2.8] | <0.001 |
| Right Ventricular Stroke Work Index (mmHg ml/m2) | 604 [456–795] | 511 [354–665] | 0.001 | 369 [322–432] | <0.001 |
| Pulmonary Vascular Resistance (Wood units) | 4.7 [3.5–6.3] | 2.2 [1.4–3.3] | <0.001 | 1.37 [0.95–2.0] | <0.001 |
| Transpulmonary Gradient (mmHg) | 18.3 [16.3–21.8] | 8.3 [5.7–11.7] | <0.001 | 6.3 [4.7–8.3] | <0.001 |
| Diastolic Pulmonary Gradient (mmHg) | 9.0 [8.0–11.0] | 0 [−3.0–3.0] | <0.001 | 1 [−1.0–3.0] | <0.001 |
| RA/PCWP | 0.54 [0.42–0.69] | 0.40 [0.29–0.56] | <0.001 | 0.4 [0.25–0.57] | <0.001 |
No variable was missing in more than 3.3% of participants.
Data presented as median [interquartile range]
†
DPG ≥7 vs. DPG <7; Rank Sum test unless otherwise indicated
‡
Comparison of all three groups; ANOVA unless otherwise indicated
*
Chi-square; () = Percentage