Table 4.

Hazard of death for participants for a variety of commonly used TPG and PVR cut-offs.

	Hazard Ratio per interquartile range (95% CI)	p-value
TPG: Cut-off 6mmHg
(362 participants with high TPG, 107 with low TPG)
Unadjusted	1.26 (0.90–1.78)	0.18
Adjusted	1.29 (0.91–1.84)	0.16
TPG: Cut-off 9mmHg
(236 participants with high TPG, 233 with low TPG)
Unadjusted	1.34 (1.01–1.77)	0.04
Adjusted	1.34 (1.00–1.79)	0.05
TPG: Cut-off 12mmHg
(152 participants with high TPG, 317 with low TPG)
Unadjusted	1.24 (0.92–1.66)	0.14
Adjusted	1.19 (0.88–1.60)	0.26
TPG: Cut-off 15mmHg
(89 participants with high TPG, 380 with low TPG)
Unadjusted	0.91 (0.60–1.38)	0.66
Adjusted	0.93 (0.61–1.42)	0.74
PVR: Cut-off 2WU
(298 participants with high PVR, 171 with low PVR)
Unadjusted	1.60 (1.18–2.18)	0.003
Adjusted	1.48 (1.07–2.03)	0.02
PVR: Cut-off 2.5WU
223 participants with high PVR, 246 with low PVR)
Unadjusted	1.78 (1.34–2.36)	<0.001
Adjusted	1.59 (1.18–2.13)	0.002
PVR: Cut-off 3WU
184 participants with high PVR, 285 with low PVR)
Unadjusted	1.79 (1.35–2.36)	<0.001
Adjusted	1.57 (1.18–2.10)	0.002
PVR: Cut-off 3.5WU
(132 participants with high PVR, 337 with low PVR)
Unadjusted	1.60 (1.18–2.18)	0.003
Adjusted	1.48 (1.07–2.03)	0.02

Adjusted model accounts for age, gender, race and body mass index

TPG = Transpulmonary Gradient. PVR = Pulmonary Vascular Resistance. WU= Wood units. CI: Confidence Intervals