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. Author manuscript; available in PMC: 2016 Mar 15.
Published in final edited form as: Int J Cancer. 2014 Aug 5;136(6):1321–1332. doi: 10.1002/ijc.29094

Figure 4.

Figure 4

Runx2 promotes lung metastasis. Mice examined in Fig. 3 for bone tumor growth were also examined by Xenogen imaging for presence of tumor cells in lung. (A) Representative images show the extent of lung metastasis in three mice from each group (n=6) 5 weeks after intratibial injection. (B) Quantitation of incidence of lung metastasis in GFP, Runx2 WT and Runx2 mutant groups. (n=6, except for n=5 in ΔC group, as indicated). (C) Quantitative analysis of metastatic cells in lungs by bioluminescence analysis. Statistical analysis (Student’s t-test) was done by comparing the values of WT group with the other three groups. *p<0.01.