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Level of AFB1-DNA adducts in maternal (C57BL/6J) and fetal (B6C3F1) liver six hr after treatment with 5 mg/kg AFB1 administered via i.p. injection or oral gavage.
| AFB1 adducts/106 nucleotides | ||||
|---|---|---|---|---|
| i.p. injection | Oral gavage | |||
| Fetus (n=12) | Mother (n=2) | Fetus (n=10) | Mother (n=2) | |
| AFB1-N7-Gua | 0.31 ± 0.25 | 18.5 ± 2.5 | 0.07 ± 0.04 | 6.2 ± 0.8 |
| AFB1-FAPY | 0.30 ± 0.19 | 45 ± 6 | <LOQ* | 19.1 ± 0.4 |
| Total | 0.62 ± 0.31 | 63.5 ± 8 | N/A | 25.3 ± 1.2 |
Mean ± SD
Limit of Quantitation
