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. Author manuscript; available in PMC: 2016 Mar 15.
Published in final edited form as: Int J Cancer. 2014 Aug 7;136(6):1254–1262. doi: 10.1002/ijc.29102

Table 2.

Influence of developmental stage on the relative risk of gpt mutations in liver from AFB1-DNA adducts after treatment with 6 mg/kg of AFB1 administered via i.p. injection.

Fetus Adult
AFB1-DNA adducts (adducts/106 bases) 0.62 63.5
10 wk gpt MF (×10−6) 6.5 30
gpt MF/DNA adducts 10 0.5
Relative risk of mutation1 20 1
Mitotic Index (liver)2 80 <1
1

Mutation risk relative to adult liver = [gpt MF/DNA adducts]/[gpt MF/DNA adducts]adult

2

Determined by Ki67 staining