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Influence of developmental stage on the relative risk of gpt mutations in liver from AFB1-DNA adducts after treatment with 6 mg/kg of AFB1 administered via i.p. injection.
| Fetus | Adult | |
|---|---|---|
| AFB1-DNA adducts (adducts/106 bases) | 0.62 | 63.5 |
| 10 wk gpt MF (×10−6) | 6.5 | 30 |
| gpt MF/DNA adducts | 10 | 0.5 |
| Relative risk of mutation1 | 20 | 1 |
| Mitotic Index (liver)2 | 80 | <1 |
Mutation risk relative to adult liver = [gpt MF/DNA adducts]/[gpt MF/DNA adducts]adult
Determined by Ki67 staining
