(a) Fiber density in the center of the burn wound was significantly elevated relative to control tissue, and significant increases in density were identified from 3 weeks through 6 months. Changes in fiber density with respect to time were attenuated at the wound edge, but significantly higher density was detected at 3 days, 2 months, and 6 months relative to control. No differences in fiber density were detected in the regions adjacent to the wound. (b) Directional variance began to decrease after 3 weeks, with significant differences relative to control detected at 2 and 6 months. No significant differences in fiber alignment were detected at the wound edge or adjacent tissue.