Table 5.
Parameters of the control and 3 HCM subgroups
| Variable | Control (n = 31) | Subgroup A (n = 17) | Subgroup B (n = 5) | Subgroup C (n = 5) | P-value |
|---|---|---|---|---|---|
| Age (yrs) | 49.3 ± 6.4 | 51.1 ± 11.1 | 52.4 ± 12.6 | 66.4 ± 10.7 | >0.05 |
| BMI (Kg/m2) | 24.6 ± 3.3 | 25.4 ± 4.5 | 25.4 ± 5.4 | 27.9 ± 4.7 | 0.391 |
| LVMI (g/m2) | 78.3 ± 21.7 | 120.1 ± 26.6 | 145.2 ± 51.3 | 127.4 ± 20.0 | >0.05* |
| LVEDD (mm) | 43.7 ± 5.9 | 42.7 ± 6.1 | 43.0 ± 6.9 | 48.0 ± 2.4 | 0.424 |
| LVESD (mm) | 25.8 ± 5.5 | 24.9 ± 5.2 | 24.4 ± 5.8 | 30.2 ± 4.6 | 0.152 |
| LVEF (%) | 69 ± 6 | 72 ± 9 | 74 ± 7 | 65 ± 9 | 0.169 |
| Baseline E/Emlateral | 6.5 ± 1.5 | 6.8 ± 1.4 | 8.0 ± 2.5 | 11.8 ± 1.2 | <0.001 |
| Stress E/Emlateral | 7.1 ± 1.3 | 7.3 ± 1.3 | 10.5 ± 0.4 | 14.0 ± 2.8 | <0.001 |
| VO2max (ml/Kg) | 27.7 ± 3.9 | 24.7 ± 5.0 | 24.8 ± 6.3 | 22.3 ± 5.1 | <0.05 |
| VE/VCO2 slope | 26.9 ± 2.7 | 27.4 ± 4.2 | 30.7 ± 1.9 | 31.3 ± 2.6 | <0.01 |
| Baseline LnNTproBNP | 3.9 ± 0.8 | 5.5 ± 1.4 | 7.4 ± 0.8 | 6.7 ± 0.6 | <0.01 |
| Stress LnNTproBNP | 4.0 ± 0.8 | 5.6 ± 1.4 | 7.5 ± 0.7 | 6.9 ± 0.6 | <0.01 |
*groups A, B and C were not different, all above the control.
BMI: body mass index; LVMI: left ventricular mass index; LVEDD: left ventricular end-diastolic dimension; LVESD: left ventricular end-systolic dimension; LVEF: left ventricle ejection fraction; VO2max: maximal oxygen consumption; VE/VCO2 slope: relationship between minute ventilation and carbon dioxide production; NT-proBNP: N-terminal pro-brain natriuretic peptide; E: early diastolic transmitral flow; Emlateral: early diastolic lateral mitral annulus velocity.