Table 4.

Cardiac and vascular surgeries

Author and year	Comparator and patients per arm (n)	Primary endpoint	Principal results
Krishnan 2009 [6]	Floseal® (1,603)	Length of hospital stay	Floseal® was associated with a lower likelihood of exceeding the expected LOS compared with baseline (OR = 0.791; p < 0.01)
	Surgicel® + thrombin (17,507)
	Gelfoam® + thrombin (10,348)
	Other (7,492)
Nasso 2009 [9]	Floseal® (209)	Rate of successful intraoperative haemostasis and time required for haemostasis	Significantly higher rates of successful haemostasis and a shorter time to haemostasis were observed in the Floseal® group (p < 0.001 both)
	Topical haemostatic agent
	(Surgicel® or Gelfoam®) (206)
Sugarman 2013 [8]	Economic comparison with 2009 Nasso study	Economic value when using Floseal® to achieve haemostasis	The use of Floseal® resulted in substantial net cost savings.