Table 6.

Tonsillectomy and adenoidectomy

Author and year	Comparator and patients per arm (n)	Primary endpoint	Principal results
Jo 2007 [15]	Floseal® (34)	Postoperative recovery time and morbidity	Floseal® decreased postoperative pain and narcotic pain medication use (p < 0.05 both) and resulted in a faster return to regular diet and activity (p < 0.01 both). Also shorter operative times were observed (p < 0.0001) and less blotod loss (p < 0.05) with Floseal®
	Electrocautery (34)
Blackmore 2008 [12]	Ligatures (one fossa randomised to Floseal® and the other to ligatures) (30)	Postoperative pain	No reduction in pain in the Floseal® group.
Mathiasen 2004 [14]	Floseal® (35)	Time to haemostasis and blood loss	Floseal® yielded significantly shorter times to haemostasis and less blood loss (p < 0.0001 both).
	Cautery (35)
Mozet 2012 [13]	Floseal® (89)	Handling, duration, and consumption of postoperative pain medication; wound healing; and rate of postoperative haemorrhage	The Floseal® group had less postoperative pain (p = 0.074), a significantly shorter duration of pain medication use (p = 0.014), and reduced pain medication consumption/demand (p = 0.032). Not significant difference in postoperative haemorrhage.
	Bipolar electrocautery (87)