Table 5.
Application of UK-NOS triage approach combining phalangeal RA and calcaneal QUS
| Combined test phalangeal RA and Calcaneal QUS (n = 202) | UK-NOS triage approach 85% certainty level | 95% CI | UK-NOS triage approach 90% certainty level | 95% CI | UK-NOS triage approach 95% certainty level | 95% CI |
|---|---|---|---|---|---|---|
| RA T-score, upper/lower cutoff | -1.36/–2.52 | NA | -0.65/–2.75 | NA | 0.28/–3.32 | NA |
| QUS BUA, upper/lower cutoff | 101.74/89.63 | NA | 105.88/86.63 | NA | 114.5/80.09 | |
| Sensitivity (%) | 98.9 | 94.1–100 | 100 | 96.1–100 | 100 | 96.1–100 |
| Specificity (%) | 95.5 | 89.7–98.5 | 99.1 | 95.0–100 | 100 | 96.7–100 |
| PPV (%) | 87.2 | 72.6–95.7 | 94.7 | 74.0–99.9 | 100 | 54.1–100 |
| NPV (%) | 97.5 | 86.8–99.9 | 100 | 86.3–100 | 100 | 75.3–100 |
| False negative (%) | 0.5 | 0.01–2.7 | 0 | 0–0.2 | 0 | 0–3.2 |
| False positive (%) | 2.5 | 0.8–5.7 | 0.5 | 0.01–2.7 | 0 | 0–3.9 |
| DXA scans avoided (%) | 41.1 | 34.2-48.2 | 21.8 | 16.3–28.1 | 9.4 | 6.2–14.9 |
Application of UK-NOS triage approach combining phalangeal RA and calcaneal QUS at a certainty level of 85%, 90%, or 95% for each method. Abbreviations: QUS Quantitative Ultrasound, BUA Broadband Ultrasound Attenuation, RA Radiographic Absorptiometry, UK-NOS United Kingdom National Osteoporosis Society, PPV Positive Predictive Value, NPV Negative Predictive Value, DXA Dual Energy X-ray Absorptiometry, CI Confidence Interval, NA not available.