. Author manuscript; available in PMC: 2015 Jan 11.

Published in final edited form as: J Med Chem. 2010 Jul 22;53(14):5179–5185. doi: 10.1021/jm100139b

Table 2.

Binding Affinities of Truncated MLL1 Peptides to WDR5

Peptide	IC₅₀ ± SD (µM)	Ki ± SD (µM)
WIN	0.75 ± 0.10	0.16 ± 0.02
Ac-11mer	1.04 ± 0.14	0.20 ± 0.03
Ac-10mer	0.02 ± 0.004	0.003 ± 0.001
H₂N-11mer	0.08 ± 0.01	0.02 ± 0.002
Ac-9mer	29 ± 4	6.30 ± 0.80
Ac-7mer	0.16 ± 0.03	0.03 ± 0.01
Ac-6mer	0.40 ± 0.10	0.09 ± 0.02
Ac-5mer	0.75 ± 0.10	0.16 ± 0.03
Ac-4mer	0.40 ± 0.05	0.08 ± 0.01
Ac-3mer	0.54 ± 0.03	0.12 ± 0.01
Ac-2mer	125 ± 6	27 ± 1.4