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Binding Affinities of Histone 3 Peptides to WDR5
| peptide | formula | IC50 ± SD (µM) | Ki ± SD (µM) |
|---|---|---|---|
| H3-10mer | H2N-ARTKQTARKS-NH2 | 70 ± 6 | 15.10 ± 1.30 |
| Ac-H3-10mer | Ac-ARTKQTARKS-NH2 | 0.006 ± 0.002 | <0.001 |
| H3-3mer | H2N-ART-NH2 | 127 ± 12 | 27.30 ± 2.50 |
| Ac-H3-3mer | Ac-ART-NH2 | 0.08 ± 0.003 | 0.02 ± 0.001 |
| H3-10mer-K4Me | H2N-ARTK(Me)QTARKS-NH2 | 69 ± 7 | 15.00 ± 1.60 |
| H3-10mer-K4Me2 | H2N-ARTK(Me2)QTARKS-NH2 | 42 ± 6 | 9.00 ± 1.30 |
| H3-10mer-K4Me3 | H2N-ARTK(Me3)QTARKS-NH2 | 73 ± 6 | 15.60 ± 1.20 |
