Table 1.

NF-κB, p53, miR-21 and miR-34ac targeted gene programs of HNSCC tissues.

Cancer location	Genes in the network
Hypopharyngeal	ALOX12B, CCL4, CD48, IGFBP3, IRF4, LAMB3, LDHA, PCBP1, S100A2, SFN, SPP1, TMEM109
Oral cavity	ARHGAP1, ASS1, BCL2, BHMT, BMP4, CEP57, COL1A2, CPEB3, CR2, CSF1, CXCR5, DNAJC16, FAS, GNLY, GPR64, GZMB, HNRNPK, IER3, IFNB1, MMP9, NFKB2, NOD2, PERP, PLA2G4A, PLAU, PSMA2, SEMA4C, SERPINE1, SERPINF1, STAT4, TGFBI, TNC
Both locations	ALDOA, IL1B, IL6, IL8, MMP1, PTX3, SELE, TP63, TPM1,

The target genes of transcription factors and miRNAs were predicted using the matrix decomposition-based method, based on microarray datasets of hypopharyngeal [124] and oral [125] metastatic vs. non-metastatic tumor tissues. Genes are presented as uniquely identified in hypopharyngeal cancer or oral cancer, or as appearing in both locations. Genes in bold are consistent with those genes differentially expressed and predicted to be under the regulation of NF-κB and TP53 in HNSCC cell lines with different TP53 mutation status [18,19].