Table 1.
Genes similarly altered in response to ethanol in two independent experiments
| Gene | Fold change | q-value | Function | Human homolog | ||
|---|---|---|---|---|---|---|
| Exp. 1 | Exp. 2 | Exp. 1 | Exp. 2 | |||
| Upregulated | ||||||
| R151.11 | +infinity | +infinity | 0.08 | 0.07 | Unknown | Unknown |
| F54H12.9 | +infinity | +infinity | 0.06 | 0.04 | Unknown | Unknown |
| F28F8.2 (acs-2) |
229.2 | 171.3 | 0.02 | 0.04 | Acyl-CoA synthetase | Long-chain-fatty-acid- CoA ligase |
| K08C7.5 (fmo-2) |
143.8 | 26.0 | 0.02 | 0.09 | Flavin-containing monooxygenase | Dimethylaniline monooxygenase |
| K12G11.3 (sodh-1) |
107.9 | 92.2 | 0.02 | 0.04 | Sorbitol dehydrogenase | Alcohol dehydrogenase 4 |
| T22F3.11 | 104.4 | 94.3 | 0.02 | 0.04 | Unknown | Solute carrier family 17 |
| F46F2.3 | 82.6 | 78.7 | 0.02 | 0.04 | Unknown | Heterogeneous nuclear ribonucleoprotein U-like protein 1 |
| C55B7.4 (acdh-1) |
74.2 | 346.7 | 0.02 | 0.04 | Short-chain acyl-CoA dehydrogenase |
Short/branched chain specific acyl-CoA dehydrogenase |
| R09B5.6 (hacd-1) |
72.7 | 45.2 | 0.02 | 0.04 | Hydroxy-Acyl-CoA dehydrogenase |
Hydroxy-acyl-CoA dehydrogenase |
| F21C10.10 | 67.8 | 24.0 | 0.02 | 0.04 | Unknown | Unknown |
| B0507.10 | 51.7 | 44.8 | 0.02 | 0.04 | Unknown | Uncharacterized protein |
| Y39B6A.27 | 51.5 | 57.6 | 0.07 | 0.08 | Unknown | UNC93-like protein MFSD11 |
| T10H9.5 (pmp-5) |
45.9 | 57.9 | 0.02 | 0.04 | Peroxisomal membrane protein related |
ATP-binding cassette sub-family D member 4 |
| B0507.8 | 44.8 | 55.7 | 0.02 | 0.10 | Unknown | Cingulin-like protein 1 |
| C35C5.8 | 44.6 | 35.6 | 0.08 | 0.07 | Unknown | Unknown |
| F44E7.2 | 38.2 | 27.1 | 0.08 | 0.09 | Unknown | Phosphoglycolate phosphatase |
| F47G4.7 (smd-1) |
31.7 | 16.2 | 0.02 | 0.08 |
S-adenosylmethionine decarboxylase |
S-adenosylmethionine decarboxylase proenzyme |
| F41H10.8 (elo-6) |
29.4 | 16.7 | 0.02 | 0.06 | Polyunsaturated fatty acid elongase | Elongation of very long chain fatty acids protein 3 |
| R03D7.1 (metr-1) |
24.6 | 13.3 | 0.02 | 0.04 | Orthologous to human methionine synthase |
Methionine synthase |
| T26F2.3 | 22.3 | 25.0 | 0.08 | 0.04 | Unknown | Unknown |
| M02D8.4 (asns-2) |
19.7 | 10.9 | 0.02 | 0.07 | Asparagine synthetase | Asparagine synthetase |
| W06H8.2 | 18.8 | 47.8 | 0.08 | 0.04 | Unknown | Unknown |
| F11A5.9 | 18.4 | 34.9 | 0.02 | 0.04 | Unknown | Sodium-dependent phosphate transport protein 4 |
| C44B7.10 | 16.7 | 15.3 | 0.02 | 0.04 | Unknown | Unknown |
| K11C4.4 (odc-1) |
15.4 | 15.1 | 0.02 | 0.08 | Ornithine decarboxylase | Ornithine decarboxylase |
| F22G12.1 | 14.7 | 18.4 | 0.08 | 0.10 | Unknown | Trinucleotide repeat containing 15 (TNRC15) |
| F28A12.4 (asp-13) |
10.6 | 11.7 | 0.04 | 0.07 | Aspartyl protease | Gastricsin |
| Downregulated | ||||||
| F08F3.4 | −50.9 | −22.4 | 0.02 | 0.04 | Unknown | Inactive L-threonine 3- dehydrogenase |
| ZK84.7 (ins-20) |
−24.3 | −27.6 | 0.02 | 0.04 | Predicted type-alpha insulin-like molecule |
Unknown |
| T08G5.10 (mtl-2) |
−20.0 | −23.3 | 0.04 | 0.09 | Metal detoxification/homeostasis, stress adaptation |
Keratin-associated protein 5-9 |
| K05F6.10 | −15.9 | −23.5 | 0.02 | 0.04 | Unknown | Unknown |
| T09H2.1 (cyp-34A4) |
−15.0 | −16.6 | 0.04 | 0.07 | Cytochrome P450 family | Cytochrome P450 2C8 |
| F27C8.4 (spp-18) |
−12.1 | −10.1 | 0.04 | 0.07 | Saposin-like protein family | Unknown |
| K11D2.2 (asah-1) |
−8.9 | −17.1 | 0.09 | 0.04 | Orthologous to human N- acylsphingosine amidohydrolase |
N-acylsphingosine amidohydrolase 1 |
The fold change was determined by dividing the value for the ethanol-treated sample by the value for the control sample (Supplemental Tables 1 and 2). The significant genes listed were shared between the two replicate experiments and have q-values ≤ 0.1. Gene functions and human homolog information were obtained from WormBase.