Table 5.
Genes similarly expressed in low and high concentrations of ethanol in C. elegans
| Upregulated in 0.017 M ethanol (this study) and in 0.2 M ethanol (21) |
Upregulated in 0.017 M ethanol (this study) and in 1.2 M ethanol (22) |
||||
|---|---|---|---|---|---|
| Gene | Function | Human homolog | Gene | Function | Human Homolog |
| C01B10.11 | Required for locomotion/morphology |
Unknown | C10H11.3 (ugt-25) |
UDP-glucuronosyl transferase |
UDP-glucuronosyl transferase 1-1 |
| C09H5.2 (catp-3) |
Cation transporting ATPase | Potassium-transporting ATPase alpha chain |
F08G2.5 | Unknown | Dentin sialophosphoprotein |
| C34C6.3 | Unknown | Uncharacterized protein | |||
| C36A4.2 (cyp-25A2) |
Cytochrome P450 family | Cytochrome P450 3A4 | |||
| C54D10.14 | Unknown | Uncharacterized protein | |||
| F09B9.1 (oac-14) |
O-acyltransferase homolog | Unknown | |||
| F44A6.5 | Protein conserved in nematodes |
Unknown | |||
| F48D6.4 | Unknown | Unknown | |||
| K07D8.1 (mup-4) |
Novel transmembrane protein required for junctional attachments |
Neurogenic locus notch homolog protein 1 precursor |
|||
| K08C7.5 (fmo-2) |
Flavin-containing monooxygenase family |
Dimethylaniline monooxygenase |
|||
| K08F4.7 (gst-4) |
Putative glutathione- requiring prostaglandin D synthase |
Hematopoietic prostaglandin D synthase |
|||
| K11C4.4 (odc-1) |
Ornithine decarboxylase | Ornithine decarboxylase | |||
| K12G11.3 (sodh-1) |
Sorbitol dehydrogenase family |
Alcohol dehydrogenase 4 | |||
| R09B5.6 (hacd-1) |
Hydroxy-acyl-CoA dehydrogenase |
Hydroacyl-coenzyme A dehydrogenase |
|||
| T11F9.11 (dhs-19) |
Short-chain dehydrogenase | Epidermal retinol dehydrogenase |
|||
| T14B4.6 (dpy-2) |
Cuticular collagen | Collagen alpha-5 (IV) chain |
|||
| T19B10.2 | Unknown | Unknown | |||
| T21E8.1 (pgp-6) |
P-glycoprotein subclass of ABC transporter superfamily |
ATP-binding cassette sub-family B member |
|||
| T22B7.3 | Unknown | Unknown | |||
| W06D12.3 (fat-5) |
Delta-9 fatty acid desaturase | Acyl-CoA desaturase | |||
| W08F4.6 (mtl-8) |
Required for molting | Unknown | |||
| Y37A1B.5 | Unknown | Selenium-binding protein 1 |
|||
| Y62E10A.13 | Unknown | Phosphoserine phosphatase |
|||
| ZC410.5 | Unknown | Unknown | |||
| ZK1290.12 (wrt-1) |
Warthog (hedgehog-like family) |
Desert hedgehog protein | |||
| ZK666.7 (clec-61) |
C-type lectin | Unknown | |||
| B0379.7 | Unknown | Neurofilament heavy polypeptide |
C25H3.10 | Unknown | Unknown |
| C17B7.4 | Unknown | Unknown | F27C8.4 (spp-18) |
Saposin-like protein | Unknown |
| C17H12.8 | Unknown | Unknown | F53E10.4 (irg-3) |
Infection response gene |
Unknown |
| C27D8.1 | Unknown | Tau-tubulin kinase 2 | |||
| C52D10.13 (col-138) |
Collagen | Uncharacterized protein | |||
| F40E3.5 | Unknown | Serine/threonine-protein phosphatase PPI |
|||
| K07H8.6 (vit-6) |
Vitellogenin | BMP-binding endothelial regulator protein |
|||
| W09C3.7 | Unknown | Unknown | |||
| Y62H9A.4 | Unknown | Unknown | |||
| ZK520.5 (cyn-2) |
Cyclophylin | Peptidyl-prolyl cis-trans isomerase D |
|||
Annotated protein function and human homolog information based on the best BLASTp match were obtained from WormBase.